The evolution of vertebrate opioid receptors

摘要: The proteins that mediate the analgesic and other effects of opioid drugs endogenous peptides are known as receptors. Opioid receptors consist a family four closely-related belonging to large superfamily G-protein coupled three types shown unequivocally analgesia in animal models mu (MOR), delta (DOR), kappa (KOR) receptor proteins. role fourth member family, nociceptin or orphanin FQ (ORL), is not clear hyperalgesia, analgesia, no effect was reported after administration ORL agonists. There now cDNA sequences for all expressed brain six species from different classes vertebrates. This review presents comparative analysis vertebrate using bioinformatics data recent human genome studies. Results indicate arose by gene duplication, there vector divergence, MOR shows evidence rapid evolution.