Chemotherapy-induced peripheral neuropathies in hematological malignancies.

摘要: Recent developments in the treatment of hematological malignancies, especially with advent proteasome inhibitors and immunomodulatory drugs plasma cell dyscrasias, call for an increased collaboration between hematologists neurologists. This involves differentiating chemotherapy-induced peripheral neuropathies (CiPN) from disease-related neurologic complications, early recognition CiPN neuropathic pain. Multiple myeloma, Waldenstrom's macroglobulinemia light-chain amyloidosis frequently present neuropathy. In addition, multiple non-Hodgkin lymphomas leukemia's may mimic neuropathy by compression or invasion extra/intradural space. Platinum compounds, vinca alkaloids, all cause CiPN, each different often specific clinical characteristics. Early recognition, identifying distinct phenotype is crucial importance to prevent irreversible neurological damage. No recommendations can be given on use neuroprotective strategies because a lack convincing evidence. Finally, caused vinca-alkaloids, painful neurologists are best equipped treat this kind