Comparison and analysis on the serum-binding characteristics of aspirin-zinc complex and aspirin.
作者： Hua-xin Zhang , Qun Zhang , Hong-lin Wang , Li-wei Li
DOI: 10.1002/BIO.3285
关键词:
摘要: This study was designed to compare the protein-binding characteristics of aspirin-zinc complex (AZN) with those aspirin itself. AZN synthesized and interacted a model transport protein, human serum albumin (HSA). Three-dimensional fluorescence, ultraviolet-visible circular dichroism (CD) spectra were used characterize interaction HSA under physiological conditions. The mechanism explored using fluorescence quenching method thermodynamic calculation. binding site locality on demonstrated probe technique Forster non-radiation energy transfer theory. Synchronous CD employed reveal effect native conformation protein. HSA-binding results for compared consistent experimental conditions, indicated that acts as guide in when Sudlow's I, subdomain IIA molecule. Moreover, aspirin, showed greater observed constants with, but smaller changes α-helicity of, HSA, which proved might be easier have less toxicity vivo.
sci-hub.se 参考文章(45)
Zi-Qiang Xu, Qi-Qi Yang, Jia-Yi Lan, Jia-Qi Zhang, Wu Peng, Jian-Cheng Jin, Feng-Lei Jiang, Yi Liu, Interactions between carbon nanodots with human serum albumin and γ-globulins: The effects on the transportation function. Journal of Hazardous Materials. ,vol. 301, pp. 242- 249 ,(2016) , 10.1016/J.JHAZMAT.2015.08.062
Sigrun Alba Johannesdottir, Ellen T. Chang, Frank Mehnert, Morten Schmidt, Anne Braae Olesen, Henrik Toft Sørensen, Nonsteroidal anti-inflammatory drugs and the risk of skin cancer Cancer. ,vol. 118, pp. 4768- 4776 ,(2012) , 10.1002/CNCR.27406
Simona Baroni, Marco Mattu, Alessandro Vannini, Rita Cipollone, Silvio Aime, Paolo Ascenzi, Mauro Fasano, Effect of ibuprofen and warfarin on the allosteric properties of haem–human serum albumin FEBS Journal. ,vol. 268, pp. 6214- 6220 ,(2001) , 10.1046/J.0014-2956.2001.02569.X
Huiyuan Cheng, Ting Zou, Yongliang Xu, Ying Wang, Aibin Wu, Jie Dai, Yezhong Zhang, Yi Liu, Investigations on the interactions between naphthalimide-based anti-tumor drugs and human serum albumin by spectroscopic and molecular modeling methods Luminescence. ,vol. 31, pp. 88- 95 ,(2016) , 10.1002/BIO.2928
Zhenxing Chi, Rutao Liu, Yue Teng, Xiaoyan Fang, Canzhu Gao, Binding of oxytetracycline to bovine serum albumin: spectroscopic and molecular modeling investigations. Journal of Agricultural and Food Chemistry. ,vol. 58, pp. 10262- 10269 ,(2010) , 10.1021/JF101417W
Geetha Gopalsamy, David Alpers, Henry Binder, Cuong Tran, B Ramakrishna, Ian Brown, Mark Manary, Elissa Mortimer, Graeme Young, The relevance of the colon to zinc nutrition. Nutrients. ,vol. 7, pp. 572- 583 ,(2015) , 10.3390/NU7010572
Selvaraj Naveenraj, Michael Ruby Raj, Sambandam Anandan, Binding interaction between serum albumins and perylene-3,4,9,10-tetracarboxylate – A spectroscopic investigation Dyes and Pigments. ,vol. 94, pp. 330- 337 ,(2012) , 10.1016/J.DYEPIG.2012.01.010
Mehrnaz Gharagozlou, Davar M. Boghaei, Interaction of water-soluble amino acid Schiff base complexes with bovine serum albumin: fluorescence and circular dichroism studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. ,vol. 71, pp. 1617- 1622 ,(2008) , 10.1016/J.SAA.2008.06.027
David M. Rogers, Jonathan D. Hirst, First-Principles Calculations of Protein Circular Dichroism in the Near Ultraviolet† Biochemistry. ,vol. 43, pp. 11092- 11102 ,(2004) , 10.1021/BI049031N
Ananyo A Bhattacharya, Tim Grüne, Stephen Curry, Crystallographic Analysis Reveals Common Modes of Binding of Medium and Long-Chain Fatty Acids to Human Serum Albumin Journal of Molecular Biology. ,vol. 303, pp. 721- 732 ,(2000) , 10.1006/JMBI.2000.4158