Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity

摘要: The recently developed concept of cancer stem cells (CSC) sheds new light on various aspects tumor growth and progression. Here, we present a mathematical model malignancies to investigate how hierarchical organized cell population affects the fundamental properties solid malignancies. We establish that tumors modeled in CSC context more faithfully resemble human show invasive behavior, whereas without hierarchy do not. These findings are corroborated by vitro studies. In addition, provide evidence is accompanied highly altered evolutionary dynamics compared with ones predicted exist stochastic, nonhierarchical model. Our main indicate allows for significantly higher heterogeneity, which may affect therapy resistance. Moreover, fails target not only unsuccessful curing patient, but also promotes malignant features recurring tumor. include rapid expansion, increased invasion, enhanced heterogeneity.