Mouse neurotropic recombinants of influenza A viruses
作者： Jutta Bonin , C. Scholtissek
DOI: 10.1007/BF01314891
关键词:
摘要: Recombinants with known gene constellations between fowl plague virus (FPV) and various prototype influenza strains have been examined for neurovirulence in suckling mice. Strongly neurotropic recombinants were obtained from crosses FPV the N, Hong Kong, PR8, but not equi 2 or swine viruses. All highly had RNA segment 4 (HA) derived (Ptra gene) other strain. The derivation of two segments polymerase complex, namely 3 (Pol 2) 5 (NP) also 8 (NS) can modulate these properties. For example, if N addition to and/or are is further enhanced, while replacement by corresponding decreases abolishes neurovirulence. genes does seem be relevant mentioned above. Of tested, turkey England (t. Engl.) strain only one which was t. Engl. kept HA still neurotropic, those completely avirulent. results demonstrated that 1. creation mice a rare event; 2. parents should multiply well mouse lungs; 3. presence cleavable hemagglutinin necessary, sufficient. In pair FPV/turkey seems determine
springer.com
sci-hub.se 参考文章(21)
Christoph Scholtissek, Influenza Virus Genetics Advances in Genetics. ,vol. 20, pp. 1- 36 ,(1979) , 10.1016/S0065-2660(08)60544-1
R Rott, M Orlich, C Scholtissek, Attenuation of pathogenicity of fowl plague virus by recombination with other influenza A viruses nonpathogenic for fowl: nonexculsive dependence of pathogenicity on hemagglutinin and neuraminidase of the virus. Journal of Virology. ,vol. 19, pp. 54- 60 ,(1976) , 10.1128/JVI.19.1.54-60.1976
Bertram Flehmig, Angelika Vallbracht, Hans-Joachim Gerth, Influenza virus: association of mouse-lung virulence with plaque formation in mouse kidney cells. Intervirology. ,vol. 7, pp. 201- 210 ,(1976) , 10.1159/000149953
Edwin D. Kilbourne, Future influenza vaccines and the use of genetic recombinants. Bulletin of The World Health Organization. ,vol. 41, pp. 643- 645 ,(1969)
A.S Beare, T.S Hall, RECOMBINANT INFLUENZA-A VIRUSES AS LIVE VACCINES FOR MAN: Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines The Lancet. ,vol. 298, pp. 1271- 1273 ,(1971) , 10.1016/S0140-6736(71)90597-6
O. Haller, A mouse hepatotropic variant of influenza virus. Archives of Virology. ,vol. 49, pp. 99- 116 ,(1975) , 10.1007/BF01317530
Angelika Vallbracht, Bertram Flehmig, Hans-Joachim Gerth, Influenza Virus: Appearance of High Mouse-Neurovirulent Recombinants Intervirology. ,vol. 11, pp. 16- 22 ,(1979) , 10.1159/000149007
Christoph Scholtissek, Susan B. Spring, Extragenic suppression of temperature-sensitive mutations in RNA segment 8 by replacement of different rna segments with those of other influenza A virus prototype strains. Virology. ,vol. 118, pp. 28- 34 ,(1982) , 10.1016/0042-6822(82)90316-6
A. Sugiura, M. Ueda, Neurovirulence of influenza virus in mice I. Neurovirulence of recombinants between virulent and avirulent virus strains Virology. ,vol. 101, pp. 440- 449 ,(1980) , 10.1016/0042-6822(80)90457-2
F.X. Bosch, M. Orlich, H.-D. Klenk, R. Rott, The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses Virology. ,vol. 95, pp. 197- 207 ,(1979) , 10.1016/0042-6822(79)90414-8