Rehabilitating effect of vitamin E therapy on the ultrastructural changes in skeletal muscles of vitamin E-deficient rabbits

摘要: Ultrastructural repair of the morphological damages produced in nutritional muscular dystrophy was studied by refeeding dystrophic rabbits with vitamin E. Weanling (1.2 kg body weight) were fed a E-deficient diet for 24 days. Half this group then sacrificed and remainder given an initial oral dose 50 mg DL-alpha-tocopherol acetate E supplemented 28 Control animals per kilogram diet. Abnormalities muscles included streaming Z-disk, degenerated mitochondria, fragmented sacroplasmic reticulum development aggregation myelin figures. The effect therapy resulted significant muscle. Small localized sections rehabilitated muscle revealed abnormal mitochondria residual