Incidence of inactive allele CYP2D6*4 among Greek women suffering from hormone-sensitive breast cancer.

摘要: BACKGROUND The incidence of CYP2D6*4 among Caucasians is estimated up to 27%, while it present in 90% all poor metabolizers within the Caucasian population. hypothesis under question whether presence one or two non-functioning (null) alleles predicts an inferior outcome postmenopausal women with breast cancer receiving adjuvant treatment tamoxifen. aim study estimate CYP2D6*4, Greek population and more precisely females suffering from cancer. MATERIALS AND METHODS Eighty unrelated mainland female volunteers hormone-sensitive were recruited during their primary handling follow-up examination order provide samples for purification polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) genomic DNA derived buccal swabs. RESULTS individuals at least allele*4 Hellenic was be as high 30% (n = 24/80), a 95% confidence interval 20% 40%. From statistical point view, can securely stated that *4 over 20%. homozygous carriers sample occurred 8.75%, haplo-type 19.4% (n=160). CONCLUSION Although outcoming results are actually line existing data other European nations, should noted, routine CYP2D6 testing formally not recommended, clinical significance phenotype remains unclear.