Reversal of left ventricular hypertrophy in hypertensive patients treated with methyldopa: Lack of association with blood pressure control☆

摘要: Abstract Ten patients with essential hypertension and left ventricular hypertrophy were treated relatively small doses of methyldopa (500 to 750 mg/day) added long-term diuretic therapy. Sequential M mode echocardiography showed significant reduction in mass 36 weeks after addition four (359 ± 77 [standard error the mean] 235 63 g) although blood pressure was not significantly altered by treatment. In three these patients, observed as early 12 treatment (384 262 g). Neither volume ratio nor fractional shortening (3.21 0.26 2.74 0.24 0.42 0.03 0.44 0.02, respectively). There no apparent relation between changes mass. Thus, reversal cardiac antihypertensive is possible human beings; however, it seems depend on other factors besides control.