Neuromuscular responses of patients with multiple sclerosis

摘要: Muscle weakness, studied in 4 patients with multiple sclerosis (MS), was compared values from normal subjects. Twitch occlusion showed that subjects could activate their muscles maximally, but rarely achieved greater than 60% activation. In both groups, motoneuron firing rates increased linearly force. Consistent the reduced level of activation, MCV MS exceeded 17 Hz (compared approximately 24 for normals). However, right and left one patient, mean maximum were 14.2 +/- 2 8.0 Hz, her muscles, be activated to levels 92% 60%, respectively. This patient's ability achieve higher expected forces at low probably due slow muscle contractile speeds, especially 1/2-relaxation time (75 115 ms, cf. 60 ms normals), high twitch/tetanus ratio (0.4, 0.2).