High Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine in Harper, Liberia: results in vivo and analysis of point mutations.

摘要: In Liberia, little information is available on the efficacy of antimalarials against Plasmodium falciparum malaria. We measured parasitological resistance to chloroquine and sulfadoxine-pyrimethamine (SP) in Harper, south-west Liberia a 28-d study vivo. A total 50 patients completed follow-up group, 66 SP group. The failure rate was 74.0% (95% confidence interval [95% CI] 59.7-85.4%) after 14 d 84.0% CI 70.9-92.8%) 28 (no polymerase chain reaction [PCR] analysis performed detect reinfections this group). 48.5% 36.2-61.0%) 69.7% 57.1-80.4%) d, readjusted 51.5% 38.9-64.0%) taking into account detected by PCR. Genomic parasite isolates also look for point mutations associated with resistance. Genotyping revealed that all carried chloroquine-resistant K-76T at gene pfcrt, whereas triple mutation (S108N, N511, C59R) dhfr A437G dhps, both SP, were present 84% 79% pretreatment respectively. These results seriously question continued use Harper highlight urgency making alternative antimalarial therapies available. Our confirms may be high yields hitherto missing SP.