Determination of telbivudine in the plasma of chronic hepatitis B patients in long-term treatment by high-performance liquid chromatographic-tandem mass spectrometry.
作者： Bicui Chen , Li Chen , Cai Cheng , Mingkang Zhong , Xiaojin Shi
DOI: 10.1002/BMC.4140
关键词:
摘要: Creatine kinase elevation is commonly reported in telbivudine-treated patients. However, little known about the relationship between this adverse drug reaction and plasma concentration. In study, a sensitive, rapid safe quantitative bioanalytical method has been established by using LC-MS/MS for determination of telbivudine clinical study chronic hepatitis B The assay was linear dynamic 10-10,000 ng/mL range (r2 > 0.999) total analysis time 6 min method. validated applied to quantitatively determine concentration patients during long-term treatment. results revealed that creatine kinase-elevated group (707.92-2788.78 ng/mL) significantly higher than those with normal (412.63-1108.32 ng/mL). This adapted therapeutic monitoring.
sci-hub.se 参考文章(21)
Ahmed A Ali, Medhat A Al-Ghobashy, Samar F Farid, Mohamed A Kassem, None, Development and validation of LC-MS/MS assay for the determination of the prodrug Midodrine and its active metabolite Desglymidodrine in plasma of ascitic patients: Application to individualized therapy and comparative pharmacokinetics. Journal of Chromatography B. ,vol. 991, pp. 34- 40 ,(2015) , 10.1016/J.JCHROMB.2015.03.032
Xiao-Jian Zhou, Deborah M. Lloyd, George C. Chao, Nathaniel A. Brown, Absence of Food Effect on the Pharmacokinetics of Telbivudine Following Oral Administration in Healthy Subjects The Journal of Clinical Pharmacology. ,vol. 46, pp. 275- 281 ,(2006) , 10.1177/0091270005284849
Ching-Lung Lai, Seng Gee Lim, Nathaniel A. Brown, Xiao-Jian Zhou, Deborah M. Lloyd, Yin-Mei Lee, Man-Fung Yuen, George C. Chao, Maureen W. Myers, A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection Hepatology. ,vol. 40, pp. 719- 726 ,(2004) , 10.1002/HEP.20374
R HARTKOORN, S KHOO, D BACK, J TJIA, C WAITT, M CHAPONDA, G DAVIES, A ARDREY, S ASHLEIGH, S WARD, A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin. Journal of Chromatography B. ,vol. 857, pp. 76- 82 ,(2007) , 10.1016/J.JCHROMB.2007.07.005
DH Vu, RA Koster, AMA Wessels, B Greijdanus, JWC Alffenaar, DRA Uges, None, Troubleshooting carry-over of LC–MS/MS method for rifampicin, clarithromycin and metabolites in human plasma Journal of Chromatography B. ,vol. 917, pp. 1- 4 ,(2013) , 10.1016/J.JCHROMB.2012.12.023
Ann Van Eeckhaut, Katrien Lanckmans, Sophie Sarre, Ilse Smolders, Yvette Michotte, Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. Journal of Chromatography B. ,vol. 877, pp. 2198- 2207 ,(2009) , 10.1016/J.JCHROMB.2009.01.003
Josef Finsterer, Leyla Ay, Myotoxicity of telbivudine in pre-existing muscle damage Virology Journal. ,vol. 7, pp. 323- 323 ,(2010) , 10.1186/1743-422X-7-323
Ching-Lung Lai, Nancy Leung, Eng-Kiong Teo, Myron Tong, Florence Wong, Hie-Won Hann, Steven Han, Thierry Poynard, Maureen Myers, George Chao, Deborah Lloyd, Nathaniel A Brown, Telbivudine Phase II Investigator Group, A 1-Year Trial of Telbivudine, Lamivudine, and the Combination in Patients With Hepatitis B e Antigen—Positive Chronic Hepatitis B Gastroenterology. ,vol. 129, pp. 528- 536 ,(2005) , 10.1053/J.GASTRO.2005.05.053
Pei Hu, Ji Jiang, Hongyun Wang, Keith Pietropaolo, George C. Chao, Nathaniel A. Brown, Xiao-Jian Zhou, Single-Dose and Multiple-Dose Pharmacokinetics and Safety of Telbivudine After Oral Administration in Healthy Chinese Subjects The Journal of Clinical Pharmacology. ,vol. 46, pp. 999- 1007 ,(2006) , 10.1177/0091270006290623
Liaw YunFan Liaw YunFan, E Gane, N Leung, S Zeuzem, Wang YuMing Wang YuMing, Lai ChingLung Lai ChingLung, EJ Heathcote, M Manns, N Bzowej, Niu JunQi Niu JunQi, SH Han, Hwang SeongGyu Hwang SeongGyu, Y Cakaloglu, MJ Tong, G Papatheodoridis, Chen YaGang Chen YaGang, NA Brown, E Albanis, K Galil, NV Naoumov, 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B Gastroenterology. ,vol. 136, pp. 486- 495 ,(2009) , 10.1053/J.GASTRO.2008.10.026