Cancer therapy with trifunctional antibodies: linking innate and adaptive immunity.
作者： Juergen Hess , Peter Ruf , Horst Lindhofer
DOI: 10.2217/FON.11.138
关键词:
摘要: Trifunctional antibodies (trAbs) are promising novel anticancer biologics with a particular mode of action capable linking innate adaptive immunity. Based on their unique structure, trifunctional IgG-like heterodimeric antibodies, consisting nonhuman mouse and rat immunoglobulin halves able to redirect T lymphocytes, as well accessory cells, the tumor site. This recruitment immune cells is accompanied by cellular activation events elicited anti-CD3, Fcγ-receptor engagement trAbs supported proinflammatory Th1-biased cytokine milieu. All necessary immunological factors required for long-term vaccination-like effects stimulated along trAb-mediated therapeutic interventions. Thus, concerted interplay antibody-dependent cytotoxicity plus polyclonal T-cell Fcγ-receptor-driven induction long-lasting responses after initial cell elimination represent major hallmarks treatment malignan...
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