The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

摘要: Abstract The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, organization system across physiological human tissues has received little attention. Here, we used tissue RNA-sequencing profiles analyze expression and chaperones 29 main tissues. We found that relative protein-coding genes, were significantly more ubiquitously expressed all Nevertheless, differential analysis revealed most up- or down-regulated in certain tissues, suggesting they have tissue-specific roles. In agreement, upregulated skeletal muscle enriched mouse myoblasts nematode’s tissue, overlapped with are causal for diseases. also identified a distinct subset formed uniformly-expressed, cross-family core group conducting basic cellular functions was essential cell survival. Altogether, this suggests layered architecture is composed shared elements complemented by variable which give rise sensitivities, thereby contributing tissue-specificity protein misfolding Significance Statement Protein diseases, such as neurodegenerative disorders myopathies, often manifested specific even type. Enigmatically, however, typically caused mutations widely proteins. Here focused on chaperones, components machinery cells. Computational analyses large scale transcriptomes unveils uniformly differentially manner. This allows each fit quality control its requirements illuminates mechanisms underlie tissue’s susceptibility protein-misfolding