Expression of prostaglandin H synthase-2 in human brain tumors.

摘要: Numerous studies have demonstrated that prostaglandin H synthase-2 (PHS-2) is involved in gastrointestinal carcinogenesis, and nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit PHS, can reduce the risk of colon cancer. In brain tumors, elevated production its correlation to anaplastic grade gliomas been demonstrated. To determine whether increased due enhanced expression PHS-2 up-regulation has any histopathological findings we evaluated profile PHS several human glioma cell lines surgical specimens from patients with various types tumors. lines, five out six showed constitutive PHS-2, whereas PHS-1 was weakly expressed all them. All specimens, except an ependymoma, both isozymes equally, mRNA predominantly. Immunohistochemistry including glioblastomas, nine astrocytomas, meningiomas, medulloblastomas, four craniopharyngiomas, three ependymomas, neurinomas, two oligodendrogliomas, malignant lymphomas, dysembryoplastic neuroepitherial tumors one metastatic tumor staining most cases. gliomas, astrocytomas (grade 2 3) were strongly stained, but intensity glioblastomas relatively weak. Meningiomas a also stained. Our data thus suggest express may play role tumorigenesis brain.