Small molecule inhibition of Csk alters affinity recognition by T cells
作者： Boryana N Manz , Ying Xim Tan , Adam H Courtney , Florentine Rutaganira , Ed Palmer
DOI: 10.7554/ELIFE.08088
关键词:
摘要: … effects of Csk inhibition has differential effects on CD4+ vs CD8+ T cells. However, we found that CD4+ and CD8+ T cells have identical responses to Csk inhibition when normalized to …
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sci-hub.st 参考文章(35)
M. Bergman, T. Mustelin, C. Oetken, J. Partanen, N.A. Flint, K.E. Amrein, M. Autero, P. Burn, K. Alitalo, The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. The EMBO Journal. ,vol. 11, pp. 2919- 2924 ,(1992) , 10.1002/J.1460-2075.1992.TB05361.X
A.C. Chan, M. Dalton, R. Johnson, G.H. Kong, T. Wang, R. Thoma, T. Kurosaki, Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. The EMBO Journal. ,vol. 14, pp. 2499- 2508 ,(1995) , 10.1002/J.1460-2075.1995.TB07247.X
Wolfgang Paster, Christian Paar, Paul Eckerstorfer, Andrea Jakober, Karel Drbal, Gerhard J. Schütz, Alois Sonnleitner, Hannes Stockinger, Genetically Encoded Förster Resonance Energy Transfer Sensors for the Conformation of the Src Family Kinase Lck Journal of Immunology. ,vol. 182, pp. 2160- 2167 ,(2009) , 10.4049/JIMMUNOL.0802639
Robert J Salmond, Rebecca J Brownlie, Vicky L Morrison, Rose Zamoyska, The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals Nature Immunology. ,vol. 15, pp. 875- 883 ,(2014) , 10.1038/NI.2958
Julie Zikherman, Craig Jenne, Susan Watson, Kristin Doan, William Raschke, Christopher C. Goodnow, Arthur Weiss, CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic Development Immunity. ,vol. 32, pp. 342- 354 ,(2010) , 10.1016/J.IMMUNI.2010.03.006
Knut Martin Torgersen, Torkel Vang, Hilde Abrahamsen, Sheraz Yaqub, Václav Hor̆ejšı́, Burkhart Schraven, Bent Rolstad, Tomas Mustelin, Kjetil Taskén, Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts Journal of Biological Chemistry. ,vol. 276, pp. 29313- 29318 ,(2001) , 10.1074/JBC.C100014200
Inmoo Rhee, André Veillette, Protein tyrosine phosphatases in lymphocyte activation and autoimmunity Nature Immunology. ,vol. 13, pp. 439- 447 ,(2012) , 10.1038/NI.2246
Konstantina Nika, Cristiana Soldani, Mogjiborahman Salek, Wolfgang Paster, Adrian Gray, Ruth Etzensperger, Lars Fugger, Paolo Polzella, Vincenzo Cerundolo, Omer Dushek, Thomas Höfer, Antonella Viola, Oreste Acuto, Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity. ,vol. 32, pp. 766- 777 ,(2010) , 10.1016/J.IMMUNI.2010.05.011
Ondřej Ballek, Jan Valečka, Jasper Manning, Dominik Filipp, The pool of preactivated Lck in the initiation of T-cell signaling: a critical re-evaluation of the Lck standby model. Immunology and Cell Biology. ,vol. 93, pp. 384- 395 ,(2015) , 10.1038/ICB.2014.100
Mayumi Naramura, Ihn-Kyung Jang, Hemanta Kole, Fang Huang, Diana Haines, Hua Gu, c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation Nature Immunology. ,vol. 3, pp. 1192- 1199 ,(2002) , 10.1038/NI855