Anti-fgfr2/3 antibodies and methods using same

作者: Avi Ashkenazi , Junichiro Sonoda , Yiyuan Yin , Paul J. Carter , Mark Chen

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摘要: The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, compositions comprising methods of using these antibodies.

参考文章(236)
Roberto DiRenzo, Rajiv Bassi, James Tonra, Maria Malabunga, Paul Kussie, Haijun Sun, Juqun Shen, David Surguladze, Marie Prewett, Neutralizing antibody against FGFR3 shows anti-tumor effects in multiple tumor models in vivo Cancer Research. ,vol. 67, pp. 2080- 2080 ,(2007)
Chezian Somasundaram, Karuna Sundarapandiyan, Tibor Keler, Yashwant M. Deo, Robert F. Graziano, Development of a trispecific antibody conjugate that directs two distinct tumor-associated antigens to CD64 on myeloid effector cells. Human antibodies. ,vol. 9, pp. 47- 54 ,(1999) , 10.3233/HAB-1999-9105
Robert E. Hawkins, Stephen J. Russell, Greg Winter, Selection of phage antibodies by binding affinity. Mimicking affinity maturation. Journal of Molecular Biology. ,vol. 226, pp. 889- 896 ,(1992) , 10.1016/0022-2836(92)90639-2
Hennie R. Hoogenboom, Greg Winter, By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. Journal of Molecular Biology. ,vol. 227, pp. 381- 388 ,(1992) , 10.1016/0022-2836(92)90894-P
Sarita Chaubal, Stephan Lang, Bärbel Schmitt, Reinhard Zeidler, Horst Lindhofer, Gilbert Reisbach, Barbara Wollenberg, Simultaneous Activation of T Cells and Accessory Cells by a New Class of Intact Bispecific Antibody Results in Efficient Tumor Cell Killing Journal of Immunology. ,vol. 163, pp. 1246- 1252 ,(1999)
Thomas A. Kunkel, Katarzyna Bebenek, John McClary, Efficient site-directed mutagenesis using uracil-containing DNA Methods in Enzymology. ,vol. 204, pp. 125- 139 ,(1991) , 10.1016/0076-6879(91)04008-C
A.D. Griffiths, M. Malmqvist, J.D. Marks, J.M. Bye, M.J. Embleton, J. McCafferty, M. Baier, K.P. Holliger, B.D. Gorick, N.C. Hughes-Jones, Human anti‐self antibodies with high specificity from phage display libraries. The EMBO Journal. ,vol. 12, pp. 725- 734 ,(1993) , 10.1002/J.1460-2075.1993.TB05706.X
Philip R. Hamann, Lois M. Hinman, Roslyn Wallace, Frederick E. Durr, Janis Upeslacis, Ana T. Menendez, Preparation and Characterization of Monoclonal Antibody Conjugates of the Calicheamicins: A Novel and Potent Family of Antitumor Antibiotics Cancer Research. ,vol. 53, pp. 3336- 3342 ,(1993)
Elizabeth E Plowright, Zhihua Li, P Leif Bergsagel, Marta Chesi, Dwayne L Barber, Donald R Branch, Robert G Hawley, A Keith Stewart, None, Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis Blood. ,vol. 95, pp. 992- 998 ,(2000) , 10.1182/BLOOD.V95.3.992.003K29_992_998
H Waldmann, M J Lockyer, D G Hassal, G Hale, A Angel, M J Sims, A P Lewis, S Brett, W Rowan, J S Crowe, A humanized CD18 antibody can block function without cell destruction. Journal of Immunology. ,vol. 151, pp. 2296- 2308 ,(1993)