Where, when, and in what form does sporadic Alzheimer's disease begin?
作者： Heiko Braak , Kelly Del Tredici
DOI: 10.1097/WCO.0B013E32835A3432
关键词:
摘要: Purpose of reviewIntraneuronal lesions consisting abnormal tau protein are seen to develop from the beginning until end-phase pathological process underlying Alzheimer's disease. This review highlights earliest phase this process.Recent findingsDevelopment freque
wkhealth.com参考文章(56)
Toshiki Uchihara, Ayako Nakamura, Mineo Yamazaki, Osamu Mori, Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence. Acta Neuropathologica. ,vol. 101, pp. 535- 539 ,(2001) , 10.1007/S004010000306
K. Iqbal, I. Grundke-Iqbal, Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. Journal of Cellular and Molecular Medicine. ,vol. 12, pp. 38- 55 ,(2007) , 10.1111/J.1582-4934.2008.00225.X
Toshiki Uchihara, Ayako Nakamura, Mineo Yamazaki, Osamu Mori, Kenji Ikeda, Kuniaki Tsuchiya, Different conformation of neuronal tau deposits distinguished by double immunofluorescence with AT8 and thiazin red combined with Gallyas method. Acta Neuropathologica. ,vol. 102, pp. 462- 466 ,(2001) , 10.1007/S004010100401
Peter W. Baas, Microtubule transport in the axon. International Review of Cytology-a Survey of Cell Biology. ,vol. 212, pp. 41- 62 ,(2002) , 10.1016/S0074-7696(01)12003-6
Hailin Zheng, Tamar Amit, Orit Bar-Am, Mati Fridkin, Moussa B.H. Youdim, Silvia A. Mandel, From Anti-Parkinson's Drug Rasagiline to Novel Multitarget Iron Chelators with Acetylcholinesterase and Monoamine Oxidase Inhibitory and Neuroprotective Properties for Alzheimer's Disease Journal of Alzheimer's Disease. ,vol. 30, pp. 1- 16 ,(2012) , 10.3233/JAD-2012-120013
Toshiki Uchihara, Expanding morphological dimensions in neuropathology, from sequence biology to pathological sequences and clinical consequences. Neuropathology. ,vol. 31, pp. 201- 207 ,(2011) , 10.1111/J.1440-1789.2011.01207.X
E Köpke, Y.C. Tung, S Shaikh, A.C. Alonso, K Iqbal, I Grundke-Iqbal, Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. Journal of Biological Chemistry. ,vol. 268, pp. 24374- 24384 ,(1993) , 10.1016/S0021-9258(20)80536-5
Stanley I. Rapoport, Peter T. Nelson, Biomarkers and evolution in Alzheimer disease Progress in Neurobiology. ,vol. 95, pp. 510- 513 ,(2011) , 10.1016/J.PNEUROBIO.2011.07.006
Michel Goedert, Florence Clavaguera, Markus Tolnay, The propagation of prion-like protein inclusions in neurodegenerative diseases Trends in Neurosciences. ,vol. 33, pp. 317- 325 ,(2010) , 10.1016/J.TINS.2010.04.003
E. E. Benarroch, The locus ceruleus norepinephrine system Functional organization and potential clinical significance Neurology. ,vol. 73, pp. 1699- 1704 ,(2009) , 10.1212/WNL.0B013E3181C2937C