Concanavalin A causes an increase in sodium permeability and intracellular sodium content of pig lymphocytes.

摘要: 1. The 3mV depolarization of pig lymphocytes observed within 2 1/2 min treatment with concanavalin A [Felber & Brand (1983) Biochem. J. 210, 885-891] is dependent on the presence high extracellular [Na+]. 2. A-induced changes in membrane potential at and low [Na+] are quantitatively explained by an increase electrogenic permeability coefficient for Na+ (PNa). This rises from a negligible value resting cells to around 4% K+ or Cl- stimulated cells. 3. Concanavalin induces 4mM content lymphocytes. intracellular not due solely stimulation influx resulting rise PNa. 4. Thus stimulates both pathway influx, small plasma membrane, non-electrogenic pathway,