Effect of chlorpromazine upon experimental hepatic injury.

摘要: Abstract The feeding of chlorpromazine to rats did not retard their growth, nor it produce significant histologic or biochemical alterations. Administration with hepatic injury produced by bile duct ligation, high-fat, low-protein diet, carbon tetrachloride slightly depressed but lead enhancement the hepatic, histologic, changes. In contrast, its administration single cell necrosis from ethionine aggravated changes and also drop esterase increase alkaline phosphatase, as well induced hyperbilirubinemia bilirubinuria. aggravation morphologic functional manifestations ethionine-induced might serve test hepatotoxic activity substances pharmacologic action similar chlorpromazine.