Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
作者： Xuan Li , Xin-Xin Cui , Ya-Jing Chen , Ting-Ting Wu , Huaxi Xu
关键词:
摘要: … Thus, we hypothesized that FG-4592 might protect dopaminergic neurons through upregulation of HIF-1α since some studies have demonstrated it can partially across the blood brain …
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Judith Eschbach, Björn von Einem, Kathrin Müller, Hanna Bayer, Annika Scheffold, Bradley E. Morrison, K. Lenhard Rudolph, Dietmar R. Thal, Anke Witting, Patrick Weydt, Markus Otto, Michael Fauler, Birgit Liss, Pamela J. McLean, Albert R. La Spada, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer, Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Annals of Neurology. ,vol. 77, pp. 15- 32 ,(2015) , 10.1002/ANA.24294
Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert, α-Synuclein in Lewy bodies Nature. ,vol. 388, pp. 839- 840 ,(1997) , 10.1038/42166
Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. ,vol. 399, pp. 271- 275 ,(1999) , 10.1038/20459
Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease). Sleep Medicine. ,vol. 15, pp. 1288- 1301 ,(2014) , 10.1016/J.SLEEP.2014.05.009
J. Langston, P Ballard, J. Tetrud, I Irwin, Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis Science. ,vol. 219, pp. 979- 980 ,(1983) , 10.1126/SCIENCE.6823561
Thomas Hackenbeck, Regina Huber, Ruth Schietke, Karl X. Knaup, Juliana Monti, Xiaoqing Wu, Bernd Klanke, Benjamin Frey, Udo Gaipl, Bernd Wullich, Didier Ferbus, Gérard Goubin, Christina Warnecke, Kai-Uwe Eckardt, Michael S. Wiesener, The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia Biochimica et Biophysica Acta. ,vol. 1813, pp. 1- 13 ,(2011) , 10.1016/J.BBAMCR.2010.10.019
Zhidan Wu, Pere Puigserver, Ulf Andersson, Chenyu Zhang, Guillaume Adelmant, Vamsi Mootha, Amy Troy, Saverio Cinti, Bradford Lowell, Richard C. Scarpulla, Bruce M. Spiegelman, Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 Cell. ,vol. 98, pp. 115- 124 ,(1999) , 10.1016/S0092-8674(00)80611-X
Faton H. Agani, Paola Pichiule, Juan Carlos Chavez, Joseph C. LaManna, The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. Journal of Biological Chemistry. ,vol. 275, pp. 35863- 35867 ,(2000) , 10.1074/JBC.M005643200
Yuncheng Wu, Xinqun Li, Julie Xiaohong Zhu, Wenjie Xie, Weidong Le, Zhen Fan, Joseph Jankovic, Tianhong Pan, Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease Neurosignals. ,vol. 19, pp. 163- 174 ,(2011) , 10.1159/000328516
Trond Lamark, Terje Johansen, Aggrephagy: selective disposal of protein aggregates by macroautophagy. International Journal of Cell Biology. ,vol. 2012, pp. 736905- 736905 ,(2012) , 10.1155/2012/736905