Atom-economic threefold cross-couplings of triarylbismuth reagents with 2-halobenzaldehydes and pot-economic in situ Wittig functionalizations with phosphonium salts
作者： Maddali L. N. Rao , Ritesh J. Dhanorkar
DOI: 10.1039/C4RA13348J
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摘要: In this paper we report an efficient pot-economic methodology for the synthesis of ortho-olefinated biaryls. This has been achieved through atom-economic threefold cross-coupling triarylbismuth reagents with 2-halobenzaldehydes followed by in situ Wittig olefination. The overall process is a straightforward biaryls from 2-halobenzaldehydes, and phosphonium salts. approach was applied to formal medicinally important Eupomatilone-6.
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