Autoantibodies and Normal Antibodies

摘要: The proposal made here is that disease-producing autoantibodies originate from a pool of preexisting natural occurs in normal animals and humans. may, under circumstances, be precursors antibodies against exogenous antigens. They may evolve anti-self to anti-foreign by V gene mutation antigen selection “best fit” B cell clones. In pathological conditions, contrast, the retain their binding properties and, influence abnormal signals T cells, mature into vectors disease.