Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs

摘要: A growing amount of evidence suggests that a deficiency in hypocretin/orexin neurotransmission is critically involved animal and human forms narcolepsy. Since hypocretin-containing neurons innervate excite histaminergic tuberomammillary neurons, altered may also be We found significant decrease histamine content the cortex thalamus, two structures important for histamine-mediated cortical arousal, Hcrtr-2 mutated narcoleptic Dobermans. In contrast, dopamine norepinephrine contents these were elevated animals, finding consistent with our hypothesis catecholaminergic transmission animals. Considering fact promotes wakefulness, decreases account sleep abnormalities hypocretin-deficient