Key points of basic theories and clinical practice in rAd-p53 ( Gendicine ™) gene therapy for solid malignant tumors.
作者： Yi Li , Bo Li , Chun-Jie Li , Long-Jiang Li
DOI: 10.1517/14712598.2015.990882
关键词:
摘要: Introduction: Wild-type p53 gene is an essential cancer suppressor which plays important role in carcinogenesis and malignant progressions. The family participates almost all the key procedures of biology, such as programmed cell death, angiogenesis, metabolism epithelial-mesenchymal transition. mutation or functional defects are detected most solid tumors, restoration by adenovirus-mediated therapy becomes a promising treatment for patients now.Areas covered: In present review, potential therapeutic effects recombinant adenovirus rAd-p53 (Gendicine™) were reviewed to explore biological mechanism underlying therapy. Then, points drug administration discussed, including routes administration, dosage calculation cycles, based on findings preclinical clinical trials order establish stan...
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