Expression of complement receptor type 1 (CR1) on erythrocytes of paracoccidiodomycosis patients.

摘要: Complement receptor type 1 (CR1) is a membrane glycoprotein that acts as for the C3b, iC3b and C4b fragments of complement. In primates, one function erythrocytes to promote safe clearance immunocomplexes (IC) from circulation through CR1. Theoretically, in diseases characterized by high levels circulating IC, an erythrocyte CR1 (CR1/E) deficiency may favor IC deposition tissues or facilitate inappropriate activation leukocytes circulation. Depression cell immune response occurs paracoccidioidomycosis (PCM), especially more severe cases, frequently associated with serum levels. present study we quantified number CR1/E patients acute chronic forms PCM before after treatment correlated it CD4+ CD8+ T concentration peripheral blood these patients. Patients PCM, particularly those active disease who had received shorter periods time, low numbers CR1/E. addition, increase reduction CD4+/CD8+ ratio were observed. After there was significant mean form tended increased These results suggest observed phenomenon acquired could play role pathogenesis PCM.