Metabolites associated with early cognitive changes implicated in Alzheimer's disease

摘要: We investigated the metabolomics of early cognitive changes related to Alzheimer9s disease (AD) in order better understand mechanisms that could contribute stages and progression this disease. This investigation used longitudinal plasma samples from Wisconsin Registry for Prevention (WRAP), a cohort participants who were dementia free at enrollment enriched with parental history AD. Metabolomic profiles quantified 2,338 fasting among 1,206 participants, each up three study visits. Of 1,097 metabolites tested, levels seven associated executive function trajectories, including an amino acid fatty acids, but none delayed recall trajectories. Our time-varying metabolomic results suggest potential earliest signs decline. In particular, acids may be cognition manner is more complex than previously suspected.