Pre-Incisional Intravenous Low-Dose Ketamine Does Not Cause Pre- Emptive Analgesic Effect Following Caesarean Section under Spinal Anaesthesia

摘要: Background: Adequate postoperative pain relief is one of the commonest challenges faced by women who deliver caesarean section. Aim: This study was aimed at finding out effect pre-incisional administration low dose intravenous ketamine on post-operative analgesia demand time. Patients and Methods: Following approval from Hospital’s Ethical Committee, a prospective, randomised double-blind carried to evaluate pre-emptive low-dose undergoing elective section under plain bupivacaine/fentanyl spinal anaesthesia. Results: Eighty completed (83.33%) study. The results were comparable in both groups for maternal age, weight, height, gestational age parity. There no statistical difference patient characteristics between two mean time taken achieve maximal sensory level 9.3±0.91 mins Group-A Group-B 8.35±1.49 mins, p=0.260. regression segments also same women. 28.1±1.52 while had 27.6±2.10 p=0.161. first analgesic request Ketamine Group 193.44±26.53 that Placebo group 140.14±22.34 mins. duration statistically significant, p=0.0001. Conclusion: It concluded only demonstrated delayed anaesthesia not effect.