Introduction to the E2F family: protein structure and gene regulation

摘要: The E2F gene family was identified through several different types of investigations, including studies viral oncogenes, positive and negative growth regulatory proteins, cellular promoters. As described below by Cobrinik, Cress Nevins, Adams Kaelin (this volume), the (which includes at least seven members) has not only been implicated in controlling expression, but also is thought to play an important role processes such as G1 S phase transition programmed cell death. To understand how this can mediate these events it first necessary examine structure regulation individual members.