Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C

摘要: To elucidate the risk factors for liver carcinogenesis and to examine incidence of hepatocellular carcinoma (HCC) after interferon therapy, 1,022 chronic hepatitis C patients treated with were followed by ultrasonography 13 97 months (median 36 months). Sustained response prolonged alanine aminotransferase normalization was found in 313 patients, transient relapse therapy 304, no 405. Forty-six developed HCC, whom 5 sustained responders, 9 32 nonresponders. The cumulative HCC responders almost equal that it significantly higher nonresponders than (P=.0009). seventh-year rates estimated be 4.3%, 4.7%, 26.1%, respectively. However, there significant difference between HCV subtype 1 2 (P=.14). Cox regression analysis showed development not elevated compared but 7.90-fold (P=.008). Patients > or =55 years age had a ratio (4.65) did those under 55 (P=.006). men 4.35 times women (P=.02). degree fibrosis factor (risk ratio, 3.16; P=.052). These results suggest high-risk group who response, older, male, such should carefully using ultrasonography.