Regulation of gene transcription by the oncoprotein MYC.

摘要: The proteins of the MYC/MAX/MAD network are central regulators many key processes associated with basic cell physiology. These include regulation protein biosynthesis, energy metabolism, proliferation, and apoptosis. Molecularly achieves these broad activities by controlling expression target genes, which primarily responsible for diverse physiological consequences elicited network. MYC possess oncogenic activity their functional deregulation is majority human tumors. Over last years we have witnessed accumulation a considerable number molecular observations that suggest different biochemical means tools controls gene expression. We will summarize more recent findings discuss how building blocks might come together to explain regulates transcription. note despite details known, do not an integrated view uses tools, neither in spatial nor temporal order.