Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity.

摘要: Abstract Olfactory neurons expressing the same odorant receptor converge to a small number of glomeruli in olfactory bulb. In turn, mitral and tufted cells receive relay this information higher cortical regions. other sensory systems, correlated neuronal activity is thought refine synaptic connections during development. We asked whether pattern between axons cell dendrites affected when odor-evoked signaling eliminated mice lacking functional cyclic nucleotide–gated (CNG) channels. demonstrate that normally CNG channel mutant background. further show pruning dendrites, although slowed development, ultimately unperturbed animals. Thus, channel—and by inference neural activity—is not required for generating specificity