HSP90 Inhibitor-Based Strategies for Cancer Therapy: Advancing Toward Clinical Impact
作者： David A. Proia , Richard C. Bates
DOI: 10.1007/978-3-319-17211-8_15
关键词:
摘要: The discovery of selective inhibitors HSP90 two decades ago has enabled both a better understanding the biology as well its validation pharmacologic target for cancer. A number have entered human clinical trials; to date, however, none been approved cancer therapy and thus full potential this class agents remains be realized. In chapter we review current status inhibitor development treatment, with particular emphasis on second-generation, synthetic classes compounds. addition, highlight various strategies currently being pursued that are designed exploit specific cell vulnerabilities provide frameworks optimization inhibitor-based across broad spectrum types.
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