Aggressive B-cell lymphomas with a primary bone marrow presentation.

摘要: Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging terms diagnostic classification and clinical handling, owing to limited architectural information. can subdivided into entities that typically primarily BM, cases with BM involvement which bulk disease is other organs. One main topic at 2018 workshop European Association Haematopathology/Society Hematopathology was therefore aggressive presentation. The submitted this gave good overview commonly encountered problems, well unusual manifestations, highlighted areas imprecise definitions grey zones. categories included Burkitt lymphoma (BL) features, high-grade (HG-BCLs) without so-called double/triple-hit, diffuse large (DLBCLs) Areas difficulties morphological boundaries HG-BCL not otherwise specified, MYC bcl-2 or bcl-6 translocations terminal deoxynucleotidyl transferase (TdT) expression, were categorised lymphoblastic leukaemia/lymphoma if most cells showed TdT positivity, clinicopathological overlap between intravascular lymphoma, CD5-positive DLBCL, DLBCL presentations spleen, liver. This review summarises our understanding common presentation potential problem areas, makes suggestions for immunophenotypic genetic work-up, illustrated by interesting workshop.