Abstract P184: Pulse Wave Velocity is Associated With Coronary Calcification and Improves its Prediction in Young And Middle-Aged Asymptomatic Adults: The Kangbuk Samsung Health Study

摘要: Introduction: The role of pulse wave velocity (PWV) in assessing cardiovascular disease (CVD) risk asymptomatic non-elderly adults is unclear. PWV assessment, however, readily available, non-invasive, cheap, and does not involve radiation exposure. Hypothesis: aim our study was to evaluate the hypothesis that brachial-ankle associated with coronary artery calcium (CAC) a large sample young middle-aged adults, increases predictive value traditional CVD factors for predicting presence CAC. Methods: Cross-sectional 15,009 men women without history who underwent health screening program included both CAC measurements. Brachial-ankle obtained from bilateral brachial posterior tibial pressure waveforms using oscillometric method. Robust tobit regression used assess association between natural log(CAC+1) logistic model detectable (CAC>0) CAC>100 adjusting multiple factors. Measures calibration discrimination were calculated test incremental adding prevalent CAC. Results: mean age participants 41.6 years (SD 7.2) 83% (12,452) men. Subjects higher had generally less favorable profiles. multivariable-adjusted score ratios (95% confidence interval) comparing quintiles 2 - 5 first quintile 1.21 (0.78, 1.86), 1.54 (1.01, 2.33), 1.98 (1.30, 3.01), 2.83 (1.84, 4.37), respectively (P trend 100 consistent results ratios. addition significantly improved models prevalence (net reclassification index [NRI] > 0.167 0.252, respectively; p<0.001). Conclusions: In this independently extent CAC. measurements improve prediction compared may help identify middle-age subjects increased subclinical disease.