Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway

摘要: Retroperitoneal operations, such as radical prostatectomy, often damage the cavernous nerve, resulting in a high incidence of erectile dysfunction. Although improved nerve-sparing techniques have reduced nerve injury, and administration phosphodiesterase type 5 inhibitors has revolutionized treatment dysfunction, this problem remains considerable challenge. In recent years, scientists focused on brain-derived neurotrophic factor vascular endothelial growth injury rat models. Results showed that both compounds were capable enhancing regeneration activation Janus kinase (JAK)/signal transducer activator transcription (STAT) pathway played major role process.