Targeting Polyamines and Inflammation for Cancer Prevention

摘要: Increased polyamine synthesis and inflammation have long been associated with intraepithelial neoplasia, which are risk factors for cancer development in humans. Targeting metabolism (by use of inhibitors or catabolism activators) nonsteroidal anti-inflammatory drugs) has studied many cancers, including colon, prostate, skin. Genetic epidemiology results indicate that a genetic variant the expression biosynthetic gene is colon prostate cancers. A clinical trial difluoromethylornithine (DFMO), selective inhibitor synthesis, showed 1 year treatment duration reduced volume serum prostate-specific antigen doubling time men family history cancer. second, DFMO combination sulindac, NSAID patients prior polyps found 3-year was 70% reduction all, over 90% advanced and/or multiple metachronous adenomas. In this chapter, we discuss similar prevention strategies targeting polyamines can be effective reducing human