Nutritional catch-up growth.

摘要: Malnutrition, marked by variant nutrient deficiencies, is considered a leading cause of stunted growth worldwide. In developing countries, malnutrition caused mainly food shortage and infectious diseases. Malnutrition may also be found in the developed world, where it due mostly to prematurity, chronic diseases, anorexia nervosa. most cases, when consumption corrected, spontaneous catch-up (CU) occurs. However, CU not always complete, deficits. Therefore, important understand mechanisms that govern this process. Using rat model restriction followed refeeding, we established nutrition-induced model. Levels leptin insulin-like factor-1 were significantly decrease was restricted increase already 1 day after refeeding. Gene expression analysis plate revealed specifically affects transcription factors such as hypoxia inducible its downstream targets on one hand, global gene expression, indicating epigenetic regulation, other. Food reduced level several microRNAs, including chondrocyte-specific miR-140, which led an target, SIRT1, class III histone deacetylase. These findings explain changes observed under nutritional manipulation. We suggest multiple levels factors, mechanisms, microRNAs respond cues offer possible explanation for some effects epiphyseal growth. The means whereby these components sense status are still unknown. Deciphering role regulation pave way development new treatments children with disorders.