Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.

摘要: Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within brain set daily rhythms sinoatrial (SA) atrioventricular (AV) node activity, impose a time-of-day dependent susceptibility ventricular arrhythmia. Critically, balance inputs from autonomic nervous system cardiomyocyte clock SA AV nodes differ, this renders cardiac conduction sensitive decoupling during abrupt shifts behavioural routine sleep-wake timing. Our findings reveal functional segregation control across heart's inherent