Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

摘要: Abstract Memory consolidation is an important process for the formation of long-term memory. We have previously reported that mature brain-derived neurotrophic factor enhances memory within 9 h after initial learning. Recent studies suggest insulin-like growth 2 (IGF2) significantly and prevents forgetting. Thus, we hypothesized IGF2 exerts its activity on cognitive performance in a time-dependent manner as observed our previous study. In one-trial step-through inhibitory avoidance task, demonstrate bilateral injection into dorsal hippocampus 6 or training enhanced latencies compared with vehicle-treated controls retention trial, which was conducted 24 h acquisition trial. However, 12 h post-training, did not increase latencies. Intriguingly, trial at 21 days training, hippocampal 6, 9 increased controls. administration discrimination index exploration time novel-located object test days, respectively, novel location recognition task. addition, IGF2-induced learning completely abolished by co-injected anti-IGF2 receptor antibody. These results learning, represents delayed phase, also critical persistence.