A Chromosome 17 Locus Engenders Frequency-Specific Non-Progressive Hearing Loss that Contributes to Age-Related Hearing Loss in Mice
作者： Braulio Peguero , Bruce L Tempel
DOI: 10.1007/S10162-015-0519-7
关键词:
摘要: The 129S6/SvEvTac (129S6) inbred mouse is known for its resistance to noise-induced hearing loss (NIHL). However, less understood of unique age-related (AHL) phenotype and potential relationship with the NIHL. Here, we studied physiological characteristics in 129S6 asked if noise (NR) AHL are genetically linked same chromosomal region. We used auditory brainstem response (ABR) distortion product otoacoustic emissions (DPOAE) examine sensitivity between 1 13 months age recombinant-inbred (congenic) mice an NR phenotype. identified a region proximal chromosome (Chr) 17 (D17Mit143-D17Mit100) that contributes sensory, non-progressive (NPHL) affecting exclusively high-frequencies (>24 kHz) maps nr1 locus on Chr 17. ABR experiments showed CBA/CaJ F1 (CBACa) hybrid exhibit normal hearing, indicating inherited recessively. An allelic complementation test 101/H (101H) strains did not rescue loss, suggesting genetic allelism nphl phl1 loci these strains, respectively. hybrids had milder than either parental strain, which indicate possible interaction other genes background or digenic different reside genomic Our study defines frequencies greater 24 kHz.
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