Gene therapy in Parkinson's disease.
作者： O. Eberhardt , J. B. Schulz
DOI: 10.1007/S00441-004-0947-X
关键词:
摘要: Gene therapy in Parkinson's disease appears to be at the brink of clinical study phase. Future gene protocols will based on a substantial amount preclinical data regarding use ex vivo and genetic modifications with help viral or non-viral vectors. To date, supplementation neurotrophic factors substitution for dopaminergic deficit have formed focus trials achieve relief animal models disease. Newer approaches include attempts influence detrimental cell signalling pathways inhibit overactive basal ganglia structures. Nevertheless, current do not mirror all aspects human disease, important issues respect long-term protein expression, choice target structures transgenes safety remain solved. Here, we thoroughly review available transfer
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