Immunoglobulins stimulate central nervous system remyelination: electron microscopic and morphometric analysis of proliferating cells.

摘要: Infection with the Daniel strain of Theiler's murine encephalomyelitis virus results in immunemediated primary demyelination spinal cords susceptible SJL/J mice. Treatment chronically infected mice (3 to 7 months) purified immunoglobulins directed against cord homogenate resulted an increase number and average size lesions that were undergoing remyelination by oligodendrocytes. In vivo autoradiography [3H]thymidine demonstrated labeling many lymphocytes areas remyelination. A direct correlation was found between labeled infiltrating lesion demyelinating lesions. Remyelinated contained proliferating cells resembled immature oligodendrocytes or progenitor glial morphologically. The presumptive correlated area However, central nervous system occurred even presence astrocytic hypertrophy. addition, treatment normal uninfected antiserum increased numbers cord. These experiments suggest a antigen may induce proliferation promote