Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis
作者： Kei Zaitsu , Munehiro Katagi , Michiaki Tatsuno , Takako Sato , Hitoshi Tsuchihashi
DOI: 10.1007/S11419-011-0111-8
关键词:
摘要: β-Keto derivatives of 3,4-methylenedioxyphenylalkylamines (bk-MDPAs), especially 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (methylone), 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one (bk-MBDB), and 2-ethylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (bk-MDEA), are abused as substitutes for in some countries, causing increased social problems. With the widespread abuse bk-MDPAs, analysis bk-MDPAs their metabolites human specimens is quite important forensic clinical toxicology. In this review, metabolisms simultaneous analytical methods by gas chromatography–mass spectrometry, liquid chromatography–tandem mass spectrometry presented.
springer.com
sci-hub.se 参考文章(37)
Alexander T. Shulgin, Psychotomimetic Drugs: Structure-Activity Relationships Springer, Boston, MA. pp. 243- 333 ,(1978) , 10.1007/978-1-4757-0510-2_6
Stefan W Toennes, Gerold F Kauert, Excretion and Detection of Cathinone, Cathine, and Phenylpropanolamine in Urine after Kath Chewing Clinical Chemistry. ,vol. 48, pp. 1715- 1719 ,(2002) , 10.1093/CLINCHEM/48.10.1715
Kei Zaitsu, Munehiro Katagi, Hiroe T. Kamata, Akihiro Miki, Hitoshi Tsuchihashi, Discrimination and identification of regioisomeric β-keto analogues of 3,4-methylenedioxyamphetamines by gas chromatography-mass spectrometry Forensic Toxicology. ,vol. 26, pp. 45- 51 ,(2008) , 10.1007/S11419-008-0050-1
Sebastian Dresen, Jürgen Kempf, Wolfgang Weinmann, Electrospray-ionization MS/MS library of drugs as database for method development and drug identification. Forensic Science International. ,vol. 161, pp. 86- 91 ,(2006) , 10.1016/J.FORSCIINT.2006.02.053
Matthew A. Parker, Danuta Marona-Lewicka, Virginia L. Lucaites, David L. Nelson, David E. Nichols, A Novel (Benzodifuranyl)aminoalkane with Extremely Potent Activity at the 5-HT2A Receptor1 Journal of Medicinal Chemistry. ,vol. 41, pp. 5148- 5149 ,(1998) , 10.1021/JM9803525
B. TESTA, A. H. BECKETT, Metabolism and excretion of diethylpropion in man under acidic urine conditions. Journal of Pharmacy and Pharmacology. ,vol. 25, pp. 119- 124 ,(2011) , 10.1111/J.2042-7158.1973.TB10604.X
Nicholas V Cozzi, Michael K Sievert, Alexander T Shulgin, Peyton Jacob, Arnold E Ruoho, Inhibition of plasma membrane monoamine transporters by β-ketoamphetamines European Journal of Pharmacology. ,vol. 381, pp. 63- 69 ,(1999) , 10.1016/S0014-2999(99)00538-5
Tooru Kamata, Munehiro Katagi, Hitoshi Tsuchihashi, Metabolism and toxicological analyses of hallucinogenic tryptamine analogues being abused in Japan Forensic Toxicology. ,vol. 28, pp. 1- 8 ,(2010) , 10.1007/S11419-009-0087-9
H. T. Kamata, N. Shima, K. Zaitsu, T. Kamata, A. Miki, M. Nishikawa, M. Katagi, H. Tsuchihashi, Metabolism of the recently encountered designer drug, methylone, in humans and rats. Xenobiotica. ,vol. 36, pp. 709- 723 ,(2006) , 10.1080/00498250600780191
M. Bossong, J. Van Dijk, R. Niesink, Methylone and mCPP, two new drugs of abuse? Addiction Biology. ,vol. 10, pp. 321- 323 ,(2005) , 10.1080/13556210500350794