Increased micronuclei frequencies in couples with reproductive failure
作者： Marie Trková , Jan Kapras , Klára Bobková , Jana Stan̆ková , Blanka Mejsnarová
DOI: 10.1016/S0890-6238(00)00087-3
关键词:
摘要: A higher incidence of chromosomal instability in the infertile population is widely recognized. An increased level micronuclei has been shown to be a marker chromosome damage. Therefore, frequencies were assessed cytokinesis-blocked lymphocytes 130 patients (65 couples) with idiopathic infertility or two more spontaneous abortions, and 30 healthy fertile donors (15 couples). The frequency micronucleated cells cohort reproductive failure controls averaged 14.95 ± 6.04 per 1000 10.60 2.57 (P < 0.0001), respectively. When sums particular couples (male + female) analyzed same order, identical statistical significance was reached 0.0001). We found no effect age sex on frequency. In summary, assay revealed micronucleus suggesting possible role failure.
elsevier.com
sci-hub.se 参考文章(25)
Michael F. Fenech, The Cytokinesis-Block Micronucleus Technique Springer, Boston, MA. pp. 25- 36 ,(1996) , 10.1007/978-1-4899-0301-3_2
Dolores J. Lamb, World Health Organization Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th ed. Journal of Andrology. ,vol. 21, pp. 32- 32 ,(2000) , 10.1002/J.1939-4640.2000.TB03272.X
C.Di Giorgio, M.P. De Méo, M. Laget, H. Guiraud, A. Botta, G. Duménil, The micronucleus assay in human lymphocytes: screening for inter-individual variability and application to biomonitoring Carcinogenesis. ,vol. 15, pp. 313- 317 ,(1994) , 10.1093/CARCIN/15.2.313
H. Thierens, A. Vral, L. De Ridder, A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 360, pp. 75- 82 ,(1996) , 10.1016/0165-1161(95)00058-5
Fernand Labrie, A new approach in the hormonal treatment of prostate cancer: complete instead of partial blockade of androgens. International Journal of Andrology. ,vol. 7, pp. 1- 4 ,(1984) , 10.1111/J.1365-2605.1984.TB00755.X
Michael Fenech, The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations Mutation Research. ,vol. 285, pp. 35- 44 ,(1993) , 10.1016/0027-5107(93)90049-L
R SCARPATO, E LANDINI, L MIGLIORE, Acrocentric chromosome frequency in spontaneous human lymphocyte micronuclei, evaluated by dual-colour hybridization, is neither sex- nor age-related Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. ,vol. 372, pp. 195- 204 ,(1996) , 10.1016/S0027-5107(96)00139-X
Lia Giraldo da Silva Augusto, Sofia Rocha Lieber, Milton Artur Ruiz, Cármino Antonio de Souza, Micronucleus monitoring to assess human occupational exposure to organochlorides. Environmental and Molecular Mutagenesis. ,vol. 29, pp. 46- 52 ,(1997) , 10.1002/(SICI)1098-2280(1997)29:1<46::AID-EM6>3.0.CO;2-B
A T Natarajan, J J Boei, F Darroudi, P C Van Diemen, F Dulout, M P Hande, A T Ramalho, Current cytogenetic methods for detecting exposure and effects of mutagens and carcinogens. Environmental Health Perspectives. ,vol. 104, pp. 445- 448 ,(1996) , 10.1289/EHP.96104S3445
G.J. Köteles, I. Bojtor, S. Szirmai, J. Bérces, M. Ótos, Micronucleus frequency in cultured lymphocytes of an urban population Mutation Research\/genetic Toxicology. ,vol. 319, pp. 267- 271 ,(1993) , 10.1016/0165-1218(93)90014-5