Toxicity of aflatoxin: effects on spermatozoa, oocytes, and in vitro fertilization.

摘要: Aflatoxin B1 has been reported to have a deleterious effect on the reproductive capacity of laboratory and domestic animals. We wanted elucidate mechanistic aspect this phenomenon by determining toxic potential aflatoxin in vitro fertilizing ability oocytes epididymal sperm albino rats. In fertilization medium (IVFM) containing at concentrations 2.0, 4.0, 8.0, 16.0 ppb was cultured with obtained from superovulated healthy fertile female rats exposed cells. Epididymal capacitated IVFM, or without B1, were oocytes, rates two experiments assessed. significantly reduced mean number ova fertilized, even lowest concentration. Exposure caused significant reduction motility These results demonstrate adverse effects spermatozoa, fertilization.