Understanding cytokine and growth factor receptor activation mechanisms.

摘要: Our understanding of the detailed mechanism action cytokine and growth factor receptors – particularly our quantitative link between structure, function lags significantly behind knowledge comparable functional protein classes such as enzymes, G protein-coupled receptors, ion channels. In particular, it remains controversial whether are activated by a ligand-induced oligomerization, versus in which ligand binds to pre-associated receptor dimer or oligomer that becomes through subsequent conformational rearrangement. A major limitation progress has been relative paucity methods for performing mechanistic experiments on unmodified expressed at endogenous levels live cells. this article, we review current state activation mechanisms critically evaluate evidence against different...