Sonochemical synthesis of novel thermo-responsive polymer and tungsten dioxide composite for the temperature-controlled reversible “on-off” electrochemical detection of β-Blocker metoprolol

摘要: Abstract Thermo-responsive polymer nanocomposite based on poly (styrene-co-N-isopropylacrylamide) hybrid tungsten dioxide (WO2@PS-co-PNIPAM) was synthesized by a facile ultrasonic irradiation (Frequency; 20 kHz, power; 180 W, calorimetrically determined 5.73 W in the bath, and Type; probe) method presence of water as inisolv. The as-synthesized WO2@PS-co-PNIPAM modified glassy carbon electrode (WO2@PS-co-PNIPAM/GCE) acting reversibly switched detection for electrooxidation metoprolol (MTP), with thermal stimuli response PNIPAM. In below lower critical solution temperature (LCST), PS-co-PNIPAM expanded to embed electroactive sites WO2, MTP could not proceed via attain electronic transfer, indicating “off” state. Rather, above LCST, shrank reveal expand cyclic voltammetric background peak currents, capable undergo electro-oxidation reaction usually produce current, “on” Additionally, proposed sensor had excellent sensitivity (2.21 µA µM−1 cm−2), wide dynamic range (0.05–306 µM), low limit 0.03 µM MTP. Intriguingly, fabricated demonstrates good selectivity towards among possible interfering compounds. Eventually, WO2@PS-co-PNIPAM/GCE has been utilized analysis human blood serum samples.