A new 5-lipoxygenase selective inhibitor derived from Artocarpus communis strongly inhibits arachidonic acid-induced ear edema.

摘要: Abstract Natural compounds isolated from the Indonesian plant, Artocarpus communis , inhibit 5-lipoxygenase of cultured mastocytoma cells. One five compounds, AC-5-1, strongly inhibits with a half-inhibition dose 5 ± 0.12 × 10 −8 M. However, prostaglandin synthesizing activity is not inhibited until −5 AC-5-1 highly selective inhibitor for 5-lipoxygenase. The at M 96% leukotriene C 4 synthesis mouse peritoneal cells facilitated by calcium-ionophore. Arachidonic acid-induced ear edema mice, an in vivo inflammatory model, involving induction, dose-dependent manner. inhibition strongest any inhibitors reported previously. Since natural compound can selectively and affect inflammation, it will be interesting to investigate role leukotrienes on inflammation other physiological processes.