Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress

摘要: Apicomplexan parasites cause diseases, including malaria and toxoplasmosis, in a range of hosts, humans. These intracellular utilize pore-forming proteins that disrupt host cell membranes to either traverse cells while migrating through tissues or egress from the parasite-containing vacuole after replication. This review highlights recent insight gained newly available three-dimensional structures several known putative apicomplexan contribute traversal egress. new structural advances suggest parasite use distinct mechanisms at multiple steps life cycles. How proteolytic processing, secretion, environment, accessibility lipid receptors regulate membranolytic activities such is also discussed.