Tobacco, Alcohol, and Colorectal Tumors: A Multistep Process

摘要: Abstract A case-control study in the Cote d'Or area of France used multistep concept colorectal carcinogenesis to compare lifetime tobacco consumption and present alcohol patients with small adenomas (less than 1 cm, n = 154) or large (n 208) polyp-free controls 427). Cancer 171) were compared population 309). In men, smoking was associated risk (odds ratio 3.6 over 20 pack-years vs. nonsmokers, p < 0.001). Alcohol a factor for only, relative risks 4.2 (p 0.01), 3.0 0.05), 4.4 0.01) consumptions 20-39, 40-59, 60 g/day less 10 g/day. When controls, both independently related tumor. There no association between intakes cancer risk. women, much lower all groups, significant either observed. These data suggest first time that there is an independent effect men at different early steps adenoma-carcinoma sequence. They demonstrate usefulness such model etiologic studies on cancer.